生殖醫學

馬偕紀念醫院生殖醫學中心成立於民國75年,三十多年來秉持服務不孕症患者的理念,不斷引進最新的技術及設備,
持續加強人員訓練,通過衛福部評鑑合格的不孕症中心,同時也是衛福部委託的人工生殖科技訓練中心。
目前有5位不孕症專科醫師、5位資深胚胎師、5位國際醫療療程管理師及專業諮詢師團隊,以最專業的醫學技術,幫助不孕症患者實現為人父母的心願。

所謂不孕
在沒有避孕的情況下,經過 12 個月以上的性生活,而沒有成功受孕。
年齡超過 35 歲的婦女,懷孕能力明顯下降,若超過半年無法受孕,可以考慮提早就診。
治療流程
門診檢查 :

  1. 超音波 — 子宮、卵巢大小、肌瘤、子宮內膜異位瘤
  2. 抽血 — 甲狀腺功能、泌乳激素及 AM H * 的濃度
    * AMH( 抗穆勒氏管荷爾蒙 )— 預測卵巢中濾泡庫存量之重要指標,是目前準確度最高的一項最新檢查項目。
  3. 精液分析及精蟲染色檢查精蟲染色後放大 1000 倍,評估精蟲正常型態比例,來預測卵子受精的機率 ( 一般精蟲檢查只放大 100 倍,且沒染色 )
  4. 子宮輸卵管攝影 — 評估兩側輸卵管是否通暢、阻塞、水腫及子宮腔形狀是否有息肉或沾粘
  5. 基礎體溫的測量
  6. 返診看報告,由醫師建議使用何種方式治療

團隊成員
★不孕症專科醫師
★泌尿科醫師
★胚胎師
★國際醫療療程管理師
★諮詢團隊
❤💖💛💕ღ

💕 故事分享 💕

Thank you! The whole team at MacKay!

Please pass our thanks to our doctor and your IVF team. You’ve done a very good job.

If there’s anyone asking us for IVF, for sure we will recommend your IVF team.

 Phuc and Vy from Vietnam

Phuc and Vy, living in Vietnam and their first kid is an MPS boy, brought their son to MacKay for regular follow-up and treatment annually. Thus, they came to MacKay for PGD+IVF while decided to have the second child. After the PGD test and IVF procedure, they successfully have another baby, a healthy boy, after their first-time single frozen-thawed embryo transfer.

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IVF Journey - From Australia to Philippines to Taiwan

I remember doctor’s last words to me after he put the embryos inside me, “We have done everything, now everything is in God’s hand.”  Somehow it comforted me.  For the past 6 years and 5th attempt of IVFs, I lived in fear and heart aches of failures but doctor reminded me again that despite science there is God who can do all miracles impossible, despite fear there is hope if you have faith.

Because of my age of 43, I just have 5 to 10% of chance of getting pregnant. I am so happy we didn’t give up, my husband did not give up on me because finally we are pregnant!

Failed to have a twin but still grateful for what we believe is God’s greatest gift to us.

Thank you MacKay, thank you my doctor, thank you my loving husband, dad and thank you God!

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Thank you again! The MacKay team!

Thank you again to the MacKay team for helping us now have 2 beautiful boys. God bless you!

 Aileen from Philippines

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Our IVF Journey in Taiwan

“Truly, the happiest day of our life”

Thank you the team at MacKay Memorial Hospital!

 Eddie & Katz

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Truly, God is amazing!

Our gratitude and love to Dr. Lee, to IMSC, Ms. Lisa and to everybody at the IVF lab and clinic. Thank you very much!

 Edmar and Rogelyn

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Our Journey to parenthood- Marlene & Jim

In 2016, we chose to proceed with the IVF at MacKay Memorial Hospital because we want a stress free environment and a team who we know are the best in this field. Thank you all for making our dream come true.

Matthew 7:7

Ask and it will be given to you; seek and you will find; knock and the door will be opened to you.

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Michelle’s sharing

My husband and I already have a 2 year old son and when we were trying to have another baby, we were always unsuccessful. We tried for more than a year and when our friend told us about ivf in Taiwan, we were interested and asked about it from friends and since we heard so many successful cases, we booked a flight to Taiwan last Feb for the initial consultation. For the actual process, we travelled to Taiwan on April.

The experience was good. Dr. Lee and Ms. Sun already have a good system in place. Check up, explanation, procedure, etc. And so on my part, I never had any fear with the entire procedure. There were also some painful moments but everything is tolerable.

We came home around 1st week of May and found out I was already pregnant around May 10th. Confirmed heartbeat of twins by 10 weeks but lost one on 12th week. After that, we sought the help of a perinatogist (high risk ob), immunologist and endoc doctor. They all helped for me to have a healthy and safe pregnancy.

I have been recommending the Taiwan ivf team to couples who have difficulty on conceiving. They are very helpful, efficient, and the chances of success is very high. Like in my case, we were successful in one try only.

Michelle Go

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Jasslyn ‘s story

My husband and I have been married for about 3 years when we decided to undergo IVF treatment. We came to this decision not because we have experienced many failed work-ups but because we want to undergo a treatment with the highest success rate.

We learned about Dr. Robert Lee and MacKay Memorial Hospital from my relatives who have been successful with their IVF treatments. With their positive recommendations, we didn’t think twice about going to the same doctor and hospital.

Seeing as it was my first IVF treatment, I was scared of the whole procedure and worried about the medications I had to take. I was also worried of language and cultural barriers. However, Dr. Lee and the whole staff at MacKay really eased my worries by being very professional.

 I also found it easy to communicate with Dr. Lee and the whole staff at MacKay because they can speak fluent English.  Although the hospital is always full of people, everyone was so efficient that we didn’t have to wait long for injections, check-ups, ultrasounds, etc. This efficiency displayed by the staff at MacKay I think, makes the biggest difference compared to hospitals or clinics in the Philippines. 

 The accommodation extended by the staff of MacKay was not just limited to the IVF treatment. They also happily answered all my queries such as other things to do in Taipei and good restaurants to eat at. I truly felt comfortable with this supposedly uncomfortable procedure because of the general warmth, compassion, and helpfulness of everyone at MacKay. All these definitely made my 1st IVF experience less stressful which I think contributed a lot in helping me achieve a positive result.

Jasslyn Tan

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Bernadine’s sharing from Manila

I am a proud mother to 3 IVF babies. My eldest was made in the Philippines while my twins were made in Taiwan. I am equally grateful to both doctors and institutions for making it possible for us to become parents.

My first pregnancy came 8 years after marriage and after countless pregnancy work-ups.  My daughter who is now 8 years old was conceived thru the help of Dr. Irene Sy of Center for Reproductive Medicine in Manila. It was a fresh IVF cycle and our first attempt.  Following this, I have had 2 failed frozen embryo transfers.  Since we already have a child, we were torn between being contented with one child and giving our child a sibling companion.  Obviously, it was the benefit of our daughter that pushed us to try IVF in Taiwan.

My cousin, who underwent a successful IVF procedure in Taiwan, recommended to us Mackay Memorial Hospital.

Mackay Memorial Hospital has an International Medical Service Center that caters to international patients.  This makes it easy for foreigners who cannot speak Chinese to communicate with them, as they are fluent in English.  With the help of electronic mails, all inquiry can also be addressed.

After 6 years of trying, we were again new parents to twins, a boy and a girl.  Twice the blessings, twice the fun!  Two miracles instead of one!

Our twins are now at their terrible twos.  It is such a joy seeing two little kids greet you as you come home from work but it is also a challenge to us in so many aspects. Good luck to us!

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Deborah’s sharing from Philippinesa

After 8 years of waiting and countless fertility treatments, God has finally answered our prayers with a healthy baby girl last June 13, 2013.  She was a living proof that miracles do happen.

We would like to thank Dr. Robert Lee Kuo-Kuang of MacKay Memorial Hospital for the successful IVF.  Out of 7 eggs retrieved, only 4 were fertilized.  Of the 4 embryos, there were 2 grade 5, 1 grade 4 and 1 grade 3 embryos.  Not the best odds.  The day of the transfer, I was crying already.  I can clearly recall Dr. Lee telling me, “You only need 1 good embryo and you have one, so don’t worry.”  I held on to these words all throughout the waiting period. It served as my strength and hope.  True enough, I only need one and she is here with me now, my bundle of joy.

Thank you Dr. Lee, and to all the nurses and staff of MacKay Memorial Hospital for being an instrument in the conception of this little miracle.  This wouldn’t be possible without you.  Thank you very very very much.

Deborah Jayne Yu

infertilityphilippines.blogspot.com

This is the most frequently asked question in my blog and emails – Why did you have IVF? Why in Taiwan and why in MacKay Memorial Hospital? Here’s my answer.

These are some of the reasons why I chose to have IVF in MacKay Memorial Hospital in Taipei:

  1. Proximity wise, Taiwan is nearer to the Philippines.
  2. It was way cheaper to have IVF done in Taiwan compared to the Philippines, Singapore or US in terms of medical expenses, food and accommodation.
  3. Taiwan has a higher success rate in terms of their IVF.
  4.  I have personally spoken to quite a number of people who were successful with their IVF with Dr. Robert Lee as their ob-gyne.
  5. I find Dr. Robert Lee very professional. He knows what he is doing and I feel comfortable with him.
  6. The system in the hospital is very organized.
  7. They have an International Medical Service team that will assist you with all the things that you need. They are prompt in answering all your queries through email and they are also the ones who will help you arrange your accommodation there.
  8. Love the food in Taipei… and shopping as well!!
  9. I also felt that a change of environment would be healthy for us as we were able to escape the stress we have here in the Philippines.  We were able to rest and unwind. It was like our second honeymoon and the IVF was like our side trip instead of the other way around.  We enjoyed the trip very much and the baby is our bonus 🙂

Why IVF?

It was recommended to me by my OB then after 3 consecutive failed IUI from her, though prior to this we have also tried IUI 2x with another OB.

Given our case, the success rate was 50% according to our ob in Taiwan. That’s a 50-50 chance for us and since we have tried everything already, ivf was our last resort.

Plus the fact that my biological clock was ticking and was not getting any younger, I was determined to give ivf a try even just once only. I wouldn’t want to wake up one day and regret the fact that I did not do something when I could have done something.

To quote from Mark Twain: “Twenty years from now, you will be more disappointed by the things that you didn’t do than by the ones you did do.  So throw off the bowlines.  Sail away from the safe harbor.  Catch the trade winds in your sails.  Explore.  Dream.  Discover.”

IVF was indeed worth a try… especially with our dream of having a baby as the prize.

Deborah Jayne Yu

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Vivian and Andrian‘s story

Year 2007, the day we promised forever.

After years of trying and waiting with all our heart and with all our faith and trust to God. Mackay Taipei here we come!

It was seven o’clock in the morning. We had our first pregnancy test. For the first time it has TWO RED LINES! Thank you lord!

36 weeks, Friday, 30th of March 2012. The day we held our precious twins for the first time. At 9:44 AM Harry Adrian was born after 2 minutes at 9:46AM Philippa Viviene was born. Praise God! Twins, two little blessings sent from above. Every perfect gift is from above. James 1:17

James 1:7
Every good and perfect gift is from above, coming down from the Father of the heavenly lights, who does not change like shifting shadows.

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服務項目

子宮內人工授精(IUI)

子宮內人工授精(IUI)是以注射排卵針劑誘導排卵,超音波偵測卵泡數目、大小,調整藥物劑量,預測排卵期,在排卵日當天,將先生取出來的精液,經洗滌篩選濃縮後,將活動力良好的精子經由子宮頸管注入子宮腔,藉此達到懷孕的協助性人工生殖方式。每次的懷孕率約為20%。

適應症:
1.輕度男性不孕症
2.輕度精蟲抗體症
3.子宮頸病變
4.排卵功能不良
5.輕度子宮內膜異位症
6.不明原因不孕症

試管嬰兒(IVF-ET)

試管嬰兒(IVF-ET)是以注射排卵針劑誘導排卵,超音波偵測卵泡數目、大小,調整藥物劑量,決定取卵日,以超音波導引經由陰道將卵取出人體外,與先生的精子在體外完成受精後,培養成為胚胎,取卵後三~五日將胚胎植入子宮,黃體期藥物補充。由陰道經過子宮頸,將胚胎植入子宮腔內稱之為IVF-ET。治療時間約需3-4週。試管嬰兒的懷孕率約為50%。

適應症:
1.輸卵管阻塞或切除
2.嚴重性子宮內膜異位症
3.嚴重性男性不孕症(加做ICSI)

顯微操作技術

卵細胞質內單一精蟲顯微注射技術 ICSI(Intracytoplasmic Sperm Injection)

在顯微鏡下將一隻健康的精蟲直接注射入卵子內,可提高卵子的受精率,等受精卵發育為胚胎後再植入子宮腔。懷孕率約40-50%。

適應症:

1.對於男性不孕症如精蟲過少、活動力不良、型態畸型率偏高
2.男女病患體內含有高濃度的抗精蟲抗體,精蟲對卵子的穿透能力便會大幅的下降3.男性的精蟲數目或活動力雖然正常,但試管嬰兒療程中屢次卵子受精失敗
4.男性病患是輸精管阻塞的無精蟲症,可先施行小手術從男性的副睪丸或睪丸中取出精蟲,再進行卵細胞質內單一精蟲顯微注射技術。

目前經由特殊染色與顯微鏡放大後的觀察,根據外型正常的精子比例,可以預測精子對卵子的受精能力和懷孕率,而且預測的準確度與穩定性比現有的其他方法都高。由馬偕紀念醫院婦產科人工授精的分析結果,發現正常形態精子超過 9 % 的患者,懷孕率為29.9 %,正常形態精子比例介於 9 % 和 4 % 之間的患者,懷孕率降為18.5 %,而正常形態精子少於 4 % 的患者,懷孕率更下降為3.8 %,這項研究結果顯示如果正常形態精子多於 4 % 的患者,人工授精仍然可以當作第一線的幫忙受孕方法,但如果正常形態精子少於 4 %,人工授精便幫不上忙,必須借助試管嬰兒技術來幫忙受孕。

又根據美國Oehninger等人研究顯示,屬於正常形態精子超過 14 % 的患者,接受試管嬰兒技術的體外受精率和懷孕率很好,分別為 94.3 % 和 43.9 %,在正常形態精子比例介於 14 % 和 4 % 之間的患者,受精率和懷孕率下降為 85.7 % 和 33.3 %,但在正常形態精子少於 4 % 的患者,受精率和懷孕率則大幅下降為 44.5 % 和 8.5 %,這個結果顯示嚴重精子畸形的患者,即使運用一般試管嬰兒的技術,成功受孕的機會也是很低,必須再借助卵細胞質內單一精蟲顯微注射技術(ICSI)的技術,才能提高其受精率和懷孕率。

胚胎縮時攝影監控培養箱

採用最先進的縮時攝影監控培養箱,培養胚胎過程不需再開箱更換培養液,這些先進技術可以達到在不干擾胚胎發育的恆定狀況下,持續觀察胚胎的動態變化。同步運用AI人工智慧及大數據來標準化評估系統,進一步篩選出品質最好的胚胎來植入,可大幅增加懷孕率及活產率。

冷凍卵子

隨著社會變遷導致晚婚遲育的女性愈來愈多,從前被認為僅提供罹癌婦女冷凍卵子保留生育力的概念,現今冷凍技術愈趨成熟,趁年輕卵巢功能尚未衰退之黃金時期,可預先將卵子凍存至足夠數量,日後再進行試管嬰兒療程。

*有哪些女性適合冷凍卵子呢?

    • 卵巢功能有早衰現象(卵子庫存量指標 AMH<2 ng/dl)
    • 準備接受化療或放射線治療之女性癌症患者
    • 任何於適孕年齡或其他有卵巢早衰家族史、自體免疫疾病…等

精液冷凍

精液冷凍
1.先生因故無法配合妻子的排卵日,可以事先冷凍精蟲備用。
2.精蟲量過少者或癌症治療前,可先將精液冷凍儲存數次,日後備用。

胚胎冷凍

若有剩餘的胚胎,可以冷凍保存,來日解凍後植入子宮內,將有多次懷孕的機會。

胚胎著床前基因診斷(PGD)與胚胎著床前篩檢(PGS)

胚胎著床前基因診斷(PGD)/胚胎著床前篩檢(PGS)

 ★胚胎著床前基因診斷(PGD)

若夫妻已知有遺傳基因異常(如肌肉萎縮症、血友病、地中海型貧血等等),可將第五天的胚胎進行細胞採樣,找出正常基因的胚胎,下個週期再植入正常的胚胎。有剩餘的胚胎,可以冷凍保存,來日解凍後再植入子宮內,將有多次懷孕的機會。

★胚胎著床前篩檢(PGS)

若父母有一方有染色體異常或染色體異常家族史、多次試管失敗或習慣性流產者(流產次數2次以上)等,可將第五天的胚胎進行細胞採樣,進行檢查,選出染色體正常的胚胎,下個週期再植入正常的胚胎。懷孕率約60-80%。

協助性孵化 (AH)

早期胚胎的外圍有一圈糖蛋白,特殊蛋白和碳水化合物組成的透明層保護胚胎的發育稱為透明帶,若此透明帶太厚或太硬,將阻止晚期胚胎(囊胚期胚胎)的孵出和子宮內著床。

協助性孵化技術是以雷射在早期胚胎的透明帶外2/3層,做大面積的打薄(約1/4圈),打薄的長度約80 um,取代以前的打洞技術,打薄的透明帶仍然維持其完整性以保護胚胎的繼續發育,在透明帶加大打薄面積可以提高胚胎孵化的機會,以提高試管嬰兒的懷孕率。

根據馬偕紀念醫院生殖中心統計,曾經嘗試試管嬰兒而失敗一次的病患,經由透明帶打薄技術的輔助,胚胎植入後有60%的懷孕率,曾經失敗2次以上的病患有43.5% 的懷孕率,但先決條件是要有品質良好的胚胎才能達到如此的懷孕率。

紡錘絲觀測儀(POLSCOPE)

單一精蟲卵細胞質顯微注射技術(ICSI)解決了大部分男性不孕症的困擾,但是在精虫注射入卵細胞的過程中有10~20%的機會可能傷害卵細胞的紡綞絲,造成受精失敗或形成染色體不正常的胚胎。

紡綞絲觀測儀是在不傷害卵細胞的活性下,以高倍顯微後觀測卵細胞內紡綞絲的位置(卵子不必用藥物固定和染色),當進行精虫注射入卵細胞內時,可以閃開紡綞絲,避免影響受精卵分裂時染色體的正常分離,以致造成染色體不正常的胚胎。因此使用紡綞絲觀測儀來施行卵細胞質內單一精蟲顯微注射技術(ICSI),可以提高正常受精率和正常胚胎發育率。

精蟲染色檢查

什麼是精蟲抗體?

夫妻的任何一方把精蟲當作外來物,引起身體的免疫反應而產生的抗體即為抗精蟲抗體。這些精蟲抗體如果出現在生殖道及精蟲上和精液裡,會增加受孕困難的可能。抗精蟲抗體(Antisperm Antibodies)藉著抗原抗體複合體的形成來影響受孕,如果結合於精子的尾部則會降低精蟲的活動力,如果結合於精子的頭部則會干擾精卵的結合,影響受精,進而造成不孕。

如何治療精蟲抗體引起的不孕症

抗體量>30%,一般先嘗試1-2次子宮腔內人工授精(IUI),如果失敗2次則建議改採試管嬰兒(IVF)。但如果精蟲抗體>50%則必須採用試管嬰兒的技術治療不孕症,甚至精蟲抗體>80%則須要採用卵細胞質內單一精蟲顯微注射術的試管嬰兒(IVF-ICSI)。

精蟲檢查注意事項

抗穆勒氏管荷爾蒙(AMH)檢查

卵巢功能的好壞,是影響自然懷孕和試管嬰兒成功的重要因素,目前用來預測卵巢中卵泡的庫存量(ovarian reserve)的指標是:年齡、卵巢中小卵泡總數, 經期頭3天的血中FSH及inhibin-B濃度,排卵藥物刺激試驗(CCCT)。近來有研究報告指出:血清中抗穆勒氏管荷爾蒙(AMH)在預測卵巢卵泡的庫存量(ovarian reserve),有顯著的準確度,使得抗穆勒氏管荷爾蒙逐漸成為一項重要的預測指標。

抗穆勒氏管荷爾蒙主要是由卵巢小卵泡分泌,卵巢小卵泡數目越多,血清中抗穆勒氏管荷爾蒙(AMH)濃度越高。下列情況有可能會減少AMH的濃度:年齡增加,體重上昇,注射促性腺激素,接受化療或放射線治療以及切除卵巢。而下列情況會增加AMH的濃度:如多囊性卵巢。而懷孕或口服避孕藥並不會影響AMH的濃度。

抗穆勒氏管荷爾蒙比起其他預測卵巢功能的方法有哪些其他優勢呢?第一:隨著年齡的增加,卵巢功能會逐漸衰退,抗穆勒氏管荷爾蒙值(AMH)也隨之下降。在所有檢測卵巢功能的方法中,AMH值能最早篩檢出巢的衰竭;第二:它的濃度不受到月經週期的影響,因而任何時期抽血濃度都一樣穩定;第三:年輕女性檢查AMH值能篩檢出卵巢功能提早衰退的女性,以便即時治療生子,以免蹉跎歲月,等到計劃生子時已經為時已晚。綜合以上的研究顯示,抗穆勒氏管荷爾蒙為預測卵巢功能的一項重要指標。

💖 我們的成果 (小於等於38歲女性) 💖

人工受孕(IUI)—懷孕率約 20%
.試管嬰兒(IVF)—懷孕率約50%
.解凍胚胎植入(FET)—懷孕率約55%
.試管嬰兒累積活產率—約57%

我們的團隊


林明輝 醫師

現職
馬偕紀念醫院婦產部部主任
馬偕紀念醫院不孕症學科科主任
馬偕紀念醫院婦產部資深主治醫師
台灣生殖醫學會理事
馬偕醫學院臨床副教授

專長
不孕症、人工生殖(試管嬰兒)、
生殖內分泌、腹腔鏡及子宮鏡手術

學經歷
高雄醫學大學醫學系畢業
馬偕紀念醫院婦產部住院醫師
馬偕紀念醫院婦產部主治醫師
美國東維吉尼亞醫學院及瓊斯生殖醫學中心(Jones Institute)研究員
日本川崎醫院研修

李國光 醫師

現職
馬偕紀念醫院不孕症科資深主治醫師
台北醫學大學醫學系副教授
教育部定副教授

專長
不孕症、人工生殖(試管嬰兒)、
生殖內分泌

學經歷
高雄醫學院畢業
美國加州大學歐文醫學院長堤醫學中心生殖醫學研究員
台灣生殖醫學會理事長、常務理事
馬偕紀念醫院不孕症學科主任
馬偕紀念醫院 婦產部主任

李日升 醫師

現職
馬偕紀念醫院不孕症科主治醫師
人工生殖試管嬰兒施術醫師
台灣婦產科醫學會專科醫師

專長
不孕症、人工生殖(試管嬰兒)、
冷凍卵子、一般婦產科

學經歷
台北醫學大學醫學系畢
馬偕醫院婦產科住院醫師
馬偕醫院婦產科總醫師訓練
馬偕醫院不孕症科研究醫師訓練

洪子渝 醫師

現職
馬偕紀念醫院不孕症科主治醫師

專長
生殖內分泌、冷凍卵子、生育保存、不孕症、 試管嬰兒、子宮腔鏡、腹腔鏡、一般婦產科

學經歷
陽明大學醫學系畢業
馬偕紀念醫院婦產科住院醫師及總醫師
馬偕紀念醫院不孕症科研究醫師

邱上琪 醫師

現職
淡水馬偕紀念醫院不孕症科主治醫師

專長
生殖內分泌、冷凍卵子、生育保存、不孕症、 試管嬰兒、子宮腔鏡、一般婦產科

學經歷
加拿大多倫多大學榮譽理學士
歐盟波蘭波茲南醫學大學醫學士
馬偕醫院婦產科住院醫師
馬偕醫院婦產科總醫師訓練
馬偕醫院不孕症科研究醫師訓練