生殖医学

马偕纪念医院生殖医学中心成立于民国75年,三十多年来秉持服务不孕症患者的理念,不断引进最新的技术及设备,
持续加强人员训练,通过卫福部评鉴合格的不孕症中心,同时也是卫福部委托的人工生殖科技训练中心。
目前有5位不孕症专科医师、5位资深胚胎师、5位国际医疗疗程管理师及专业咨询师团队,以最专业的医学技术,帮助不孕症患者实现为人父母的心愿。

所谓不孕
在没有避孕的情况下,经过 12 个月以上的性生活,而没有成功受孕。
年龄超过 35 岁的妇女,怀孕能力明显下降,若超过半年无法受孕,可以考虑提早就诊。
治疗流程
门诊检查 :

超音波 — 子宫、卵巢大小、肌瘤、子宫内膜异位瘤
抽血 — 甲状腺功能、泌乳激素及 AM H * 的浓度
* AMH( 抗穆勒氏管荷尔蒙 )— 预测卵巢中滤泡库存量之重要指标,是目前准确度最高的一项最新检查项目。
精液分析及精虫染色检查精虫染色後放大 1000 倍,评估精虫正常型态比例,来预测卵子受精的机率 ( 一般精虫检查只放大 100 倍,且没染色 )
子宫输卵管摄影 — 评估两侧输卵管是否通畅、阻塞、水肿及子宫腔形状是否有息肉或沾粘
基础体温的测量
返诊看报告,由医师建议使用何种方式治疗

团队成员

★ 不孕症专科医师
★ 泌尿科医师
★ 胚胎师
★ 国际医疗疗程管理师
★ 咨询团队

💕 故事分享 💕

Thank you! The whole team at MacKay!

Please pass our thanks to our doctor and your IVF team. You’ve done a very good job.

If there’s anyone asking us for IVF, for sure we will recommend your IVF team.

 Phuc and Vy from Vietnam

Phuc and Vy, living in Vietnam and their first kid is an MPS boy, brought their son to MacKay for regular follow-up and treatment annually. Thus, they came to MacKay for PGD+IVF while decided to have the second child. After the PGD test and IVF procedure, they successfully have another baby, a healthy boy, after their first-time single frozen-thawed embryo transfer.

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IVF Journey - From Australia to Philippines to Taiwan

I remember doctor’s last words to me after he put the embryos inside me, “We have done everything, now everything is in God’s hand.”  Somehow it comforted me.  For the past 6 years and 5th attempt of IVFs, I lived in fear and heart aches of failures but doctor reminded me again that despite science there is God who can do all miracles impossible, despite fear there is hope if you have faith.

Because of my age of 43, I just have 5 to 10% of chance of getting pregnant. I am so happy we didn’t give up, my husband did not give up on me because finally we are pregnant!

Failed to have a twin but still grateful for what we believe is God’s greatest gift to us.

Thank you MacKay, thank you my doctor, thank you my loving husband, dad and thank you God!

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Thank you again! The MacKay team!

Thank you again to the MacKay team for helping us now have 2 beautiful boys. God bless you!

 Aileen from Philippines

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Our IVF Journey in Taiwan

“Truly, the happiest day of our life”

Thank you the team at MacKay Memorial Hospital!

 Eddie & Katz

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Truly, God is amazing!

Our gratitude and love to Dr. Lee, to IMSC, Ms. Lisa and to everybody at the IVF lab and clinic. Thank you very much!

 Edmar and Rogelyn

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Our Journey to parenthood- Marlene & Jim

In 2016, we chose to proceed with the IVF at MacKay Memorial Hospital because we want a stress free environment and a team who we know are the best in this field. Thank you all for making our dream come true.

Matthew 7:7

Ask and it will be given to you; seek and you will find; knock and the door will be opened to you.

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Michelle’s sharing

My husband and I already have a 2 year old son and when we were trying to have another baby, we were always unsuccessful. We tried for more than a year and when our friend told us about ivf in Taiwan, we were interested and asked about it from friends and since we heard so many successful cases, we booked a flight to Taiwan last Feb for the initial consultation. For the actual process, we travelled to Taiwan on April.

The experience was good. Dr. Lee and Ms. Sun already have a good system in place. Check up, explanation, procedure, etc. And so on my part, I never had any fear with the entire procedure. There were also some painful moments but everything is tolerable.

We came home around 1st week of May and found out I was already pregnant around May 10th. Confirmed heartbeat of twins by 10 weeks but lost one on 12th week. After that, we sought the help of a perinatogist (high risk ob), immunologist and endoc doctor. They all helped for me to have a healthy and safe pregnancy.

I have been recommending the Taiwan ivf team to couples who have difficulty on conceiving. They are very helpful, efficient, and the chances of success is very high. Like in my case, we were successful in one try only.

Michelle Go

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Jasslyn ‘s story

My husband and I have been married for about 3 years when we decided to undergo IVF treatment. We came to this decision not because we have experienced many failed work-ups but because we want to undergo a treatment with the highest success rate.

We learned about Dr. Robert Lee and MacKay Memorial Hospital from my relatives who have been successful with their IVF treatments. With their positive recommendations, we didn’t think twice about going to the same doctor and hospital.

Seeing as it was my first IVF treatment, I was scared of the whole procedure and worried about the medications I had to take. I was also worried of language and cultural barriers. However, Dr. Lee and the whole staff at MacKay really eased my worries by being very professional.

 I also found it easy to communicate with Dr. Lee and the whole staff at MacKay because they can speak fluent English.  Although the hospital is always full of people, everyone was so efficient that we didn’t have to wait long for injections, check-ups, ultrasounds, etc. This efficiency displayed by the staff at MacKay I think, makes the biggest difference compared to hospitals or clinics in the Philippines. 

 The accommodation extended by the staff of MacKay was not just limited to the IVF treatment. They also happily answered all my queries such as other things to do in Taipei and good restaurants to eat at. I truly felt comfortable with this supposedly uncomfortable procedure because of the general warmth, compassion, and helpfulness of everyone at MacKay. All these definitely made my 1st IVF experience less stressful which I think contributed a lot in helping me achieve a positive result.

Jasslyn Tan

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Bernadine’s sharing from Manila

I am a proud mother to 3 IVF babies. My eldest was made in the Philippines while my twins were made in Taiwan. I am equally grateful to both doctors and institutions for making it possible for us to become parents.

My first pregnancy came 8 years after marriage and after countless pregnancy work-ups.  My daughter who is now 8 years old was conceived thru the help of Dr. Irene Sy of Center for Reproductive Medicine in Manila. It was a fresh IVF cycle and our first attempt.  Following this, I have had 2 failed frozen embryo transfers.  Since we already have a child, we were torn between being contented with one child and giving our child a sibling companion.  Obviously, it was the benefit of our daughter that pushed us to try IVF in Taiwan.

My cousin, who underwent a successful IVF procedure in Taiwan, recommended to us Mackay Memorial Hospital.

Mackay Memorial Hospital has an International Medical Service Center that caters to international patients.  This makes it easy for foreigners who cannot speak Chinese to communicate with them, as they are fluent in English.  With the help of electronic mails, all inquiry can also be addressed.

After 6 years of trying, we were again new parents to twins, a boy and a girl.  Twice the blessings, twice the fun!  Two miracles instead of one!

Our twins are now at their terrible twos.  It is such a joy seeing two little kids greet you as you come home from work but it is also a challenge to us in so many aspects. Good luck to us!

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Deborah’s sharing from Philippinesa

After 8 years of waiting and countless fertility treatments, God has finally answered our prayers with a healthy baby girl last June 13, 2013.  She was a living proof that miracles do happen.

We would like to thank Dr. Robert Lee Kuo-Kuang of MacKay Memorial Hospital for the successful IVF.  Out of 7 eggs retrieved, only 4 were fertilized.  Of the 4 embryos, there were 2 grade 5, 1 grade 4 and 1 grade 3 embryos.  Not the best odds.  The day of the transfer, I was crying already.  I can clearly recall Dr. Lee telling me, “You only need 1 good embryo and you have one, so don’t worry.”  I held on to these words all throughout the waiting period. It served as my strength and hope.  True enough, I only need one and she is here with me now, my bundle of joy.

Thank you Dr. Lee, and to all the nurses and staff of MacKay Memorial Hospital for being an instrument in the conception of this little miracle.  This wouldn’t be possible without you.  Thank you very very very much.

Deborah Jayne Yu

infertilityphilippines.blogspot.com

This is the most frequently asked question in my blog and emails – Why did you have IVF? Why in Taiwan and why in MacKay Memorial Hospital? Here’s my answer.

These are some of the reasons why I chose to have IVF in MacKay Memorial Hospital in Taipei:

  1. Proximity wise, Taiwan is nearer to the Philippines.
  2. It was way cheaper to have IVF done in Taiwan compared to the Philippines, Singapore or US in terms of medical expenses, food and accommodation.
  3. Taiwan has a higher success rate in terms of their IVF.
  4.  I have personally spoken to quite a number of people who were successful with their IVF with Dr. Robert Lee as their ob-gyne.
  5. I find Dr. Robert Lee very professional. He knows what he is doing and I feel comfortable with him.
  6. The system in the hospital is very organized.
  7. They have an International Medical Service team that will assist you with all the things that you need. They are prompt in answering all your queries through email and they are also the ones who will help you arrange your accommodation there.
  8. Love the food in Taipei… and shopping as well!!
  9. I also felt that a change of environment would be healthy for us as we were able to escape the stress we have here in the Philippines.  We were able to rest and unwind. It was like our second honeymoon and the IVF was like our side trip instead of the other way around.  We enjoyed the trip very much and the baby is our bonus 🙂

Why IVF?

It was recommended to me by my OB then after 3 consecutive failed IUI from her, though prior to this we have also tried IUI 2x with another OB.

Given our case, the success rate was 50% according to our ob in Taiwan. That’s a 50-50 chance for us and since we have tried everything already, ivf was our last resort.

Plus the fact that my biological clock was ticking and was not getting any younger, I was determined to give ivf a try even just once only. I wouldn’t want to wake up one day and regret the fact that I did not do something when I could have done something.

To quote from Mark Twain: “Twenty years from now, you will be more disappointed by the things that you didn’t do than by the ones you did do.  So throw off the bowlines.  Sail away from the safe harbor.  Catch the trade winds in your sails.  Explore.  Dream.  Discover.”

IVF was indeed worth a try… especially with our dream of having a baby as the prize.

Deborah Jayne Yu

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Vivian and Andrian‘s story

Year 2007, the day we promised forever.

After years of trying and waiting with all our heart and with all our faith and trust to God. Mackay Taipei here we come!

It was seven o’clock in the morning. We had our first pregnancy test. For the first time it has TWO RED LINES! Thank you lord!

36 weeks, Friday, 30th of March 2012. The day we held our precious twins for the first time. At 9:44 AM Harry Adrian was born after 2 minutes at 9:46AM Philippa Viviene was born. Praise God! Twins, two little blessings sent from above. Every perfect gift is from above. James 1:17

James 1:7
Every good and perfect gift is from above, coming down from the Father of the heavenly lights, who does not change like shifting shadows.

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服务项目

子宫内人工授精(IUI)

子宫内人工授精(IUI)是以注射排卵针剂诱导排卵,超音波侦测卵泡数目、大小,调整药物剂量,预测排卵期,在排卵日当天,将先生取出来的精液,经洗涤筛选浓缩后,将活动力良好的精子经由子宫颈管注入子宫腔,藉此达到怀孕的协助性人工生殖方式。每次的怀孕率约为20%。

适应症:
1.轻度男性不孕症
2.轻度精虫抗体症
3.子宫颈病变
4.排卵功能不良
5.轻度子宫内膜异位症
6.不明原因不孕症

试管婴儿(IVF-ET)

试管婴儿(IVF-ET)是以注射排卵针剂诱导排卵,超音波侦测卵泡数目、大小,调整药物剂量,决定取卵日,以超音波导引经由阴道将卵取出人体外,与先生的精子在体外完成受精后,培养成为胚胎,取卵后三~五日将胚胎植入子宫,黄体期药物补充。由阴道经过子宫颈,将胚胎植入子宫腔内称之为IVF-ET。治疗时间约需3-4周。试管婴儿的怀孕率约为50%。

适应症:
1.输卵管阻塞或切除
2.严重性子宫内膜异位症
3.严重性男性不孕症(加做ICSI)

显微操作技术

卵细胞质内单一精虫显微注射技术 ICSI(Intracytoplasmic Sperm Injection)

在显微镜下将一只健康的精虫直接注射入卵子内,可提高卵子的受精率,等受精卵发育为胚胎后再植入子宫腔。怀孕率约40-50%。

适应症:
1.对于男性不孕症如精虫过少、活动力不良、型态畸型率偏高
2.男女病患体内含有高浓度的抗精虫抗体,精虫对卵子的穿透能力便会大幅的下降3.男性的精虫数目或活动力虽然正常,但试管婴儿疗程中屡次卵子受精失败
4.男性病患是输精管阻塞的无精虫症,可先施行小手术从男性的副睪丸或睪丸中取出精虫,再进行卵细胞质内单一精虫显微注射技术。

目前经由特殊染色与显微镜放大后的观察,根据外型正常的精子比例,可以预测精子对卵子的受精能力和怀孕率,而且预测的准确度与稳定性比现有的其他方法都高。由马偕纪念医院妇产科人工授精的分析结果,发现正常形态精子超过 9 % 的患者,怀孕率为29.9 %,正常形态精子比例介于 9 % 和 4 % 之间的患者,怀孕率降为18.5 %,而正常形态精子少于 4 % 的患者,怀孕率更下降为3.8 %,这项研究结果显示如果正常形态精子多于 4 % 的患者,人工授精仍然可以当作第一线的帮忙受孕方法,但如果正常形态精子少于 4 %,人工授精便帮不上忙,必须借助试管婴儿技术来帮忙受孕。

又根据美国Oehninger等人研究显示,属于正常形态精子超过 14 % 的患者,接受试管婴儿技术的体外受精率和怀孕率很好,分别为 94.3 % 和 43.9 %,在正常形态精子比例介于 14 % 和 4 % 之间的患者,受精率和怀孕率下降为 85.7 % 和 33.3 %,但在正常形态精子少于 4 % 的患者,受精率和怀孕率则大幅下降为 44.5 % 和 8.5 %,这个结果显示严重精子畸形的患者,即使运用一般试管婴儿的技术,成功受孕的机会也是很低,必须再借助卵细胞质内单一精虫显微注射技术(ICSI)的技术,才能提高其受精率和怀孕率。

胚胎缩时摄影监控培养箱

采用最先进的缩时摄影监控培养箱,培养胚胎过程不需再开箱更换培养液,这些先进技术可以达到在不干扰胚胎发育的恒定状况下,持续观察胚胎的动态变化。同步运用AI人工智能及大数据来标准化评估系统,进一步筛选出质量最好的胚胎来植入,可大幅增加怀孕率及活产率。

冷冻卵子

随着社会变迁导致晚婚迟育的女性愈来愈多,从前被认为仅提供罹癌妇女冷冻卵子保留生育力的概念,现今冷冻技术愈趋成熟,趁年轻卵巢功能尚未衰退之黄金时期,可预先将卵子冻存至足够数量,日后再进行试管婴儿疗程。

*有哪些女性适合冷冻卵子呢?

    • 卵巢功能有早衰现象(卵子库存量指标 AMH<2 ng/dl)
    • 准备接受化疗或放射线治疗之女性癌症患者
    • 任何于适孕年龄或其他有卵巢早衰家族史、自体免疫疾病…等

精液冷冻

1.先生因故无法配合妻子的排卵日,可以事先冷冻精虫备用。
2.精虫量过少者或癌症治疗前,可先将精液冷冻储存数次,日后备用。

胚胎冷冻

若有剩余的胚胎,可以冷冻保存,来日解冻后植入子宫内,将有多次怀孕的机会。

胚胎着床前基因诊断(PGD)与胚胎着床前筛检(PGS)

★胚胎着床前基因诊断(PGD)

若夫妻已知有遗传基因异常(如肌肉萎缩症、血友病、地中海型贫血等等),可将第五天的胚胎进行细胞采样,找出正常基因的胚胎,下个周期再植入正常的胚胎。有剩余的胚胎,可以冷冻保存,来日解冻后再植入子宫内,将有多次怀孕的机会。

★胚胎着床前筛检(PGS)

若父母有一方有染色体异常或染色体异常家族史、多次试管失败或习惯性流产者(流产次数2次以上)等,可将第五天的胚胎进行细胞采样,进行检查,选出染色体正常的胚胎,下个周期再植入正常的胚胎。怀孕率约60-80%。

透明带雷射打薄技术

协助性孵化 (AH)

早期胚胎的外围有一圈糖蛋白,特殊蛋白和碳水化合物组成的透明层保护胚胎的发育称为透明带,若此透明带太厚或太硬,将阻止晚期胚胎(囊胚期胚胎)的孵出和子宫内着床。

协助性孵化技术是以雷射在早期胚胎的透明带外2/3层,做大面积的打薄(约1/4圈),打薄的长度约80 um,取代以前的打洞技术,打薄的透明带仍然维持其完整性以保护胚胎的继续发育,在透明带加大打薄面积可以提高胚胎孵化的机会,以提高试管婴儿的怀孕率。

根据马偕纪念医院生殖中心统计,曾经尝试试管婴儿而失败一次的病患,经由透明带打薄技术的辅助,胚胎植入后有60%的怀孕率,曾经失败2次以上的病患有43.5% 的怀孕率,但先决条件是要有质量良好的胚胎才能达到如此的怀孕率。

纺锤丝观测仪(POLSCOPE)

单一精虫卵细胞质显微注射技术(ICSI)解决了大部分男性不孕症的困扰,但是在精虫注射入卵细胞的过程中有10~20%的机会可能伤害卵细胞的纺缍丝,造成受精失败或形成染色体不正常的胚胎。

纺缍丝观测仪是在不伤害卵细胞的活性下,以高倍显微后观测卵细胞内纺缍丝的位置(卵子不必用药物固定和染色),当进行精虫注射入卵细胞内时,可以闪开纺缍丝,避免影响受精卵分裂时染色体的正常分离,以致造成染色体不正常的胚胎。因此使用纺缍丝观测仪来施行卵细胞质内单一精虫显微注射技术(ICSI),可以提高正常受精率和正常胚胎发育率

精虫染色检查

什么是精虫抗体?

夫妻的任何一方把精虫当作外来物,引起身体的免疫反应而产生的抗体即为抗精虫抗体。这些精虫抗体如果出现在生殖道及精虫上和精液里,会增加受孕困难的可能。抗精虫抗体(Antisperm Antibodies)借着抗原抗体复合体的形成来影响受孕,如果结合于精子的尾部则会降低精虫的活动力,如果结合于精子的头部则会干扰精卵的结合,影响受精,进而造成不孕。

如何治疗精虫抗体引起的不孕症

抗体量>30%,一般先尝试1-2次子宫腔内人工授精(IUI),如果失败2次则建议改采试管婴儿(IVF)。但如果精虫抗体>50%则必须采用试管婴儿的技术治疗不孕症,甚至精虫抗体>80%则须要采用卵细胞质内单一精虫显微注射术的试管婴儿(IVF-ICSI)。

精蟲檢查注意事項

抗穆勒氏管荷尔蒙(AMH)检查

卵巢功能的好坏,是影响自然怀孕和试管婴儿成功的重要因素,目前用来预测卵巢中卵泡的库存量(ovarian reserve)的指标是:年龄、卵巢中小卵泡总数, 经期头3天的血中FSH及inhibin-B浓度,排卵药物刺激试验(CCCT)。近来有研究报告指出:血清中抗穆勒氏管荷尔蒙(AMH)在预测卵巢卵泡的库存量(ovarian reserve),有显著的准确度,使得抗穆勒氏管荷尔蒙逐渐成为一项重要的预测指标。

抗穆勒氏管荷尔蒙主要是由卵巢小卵泡分泌,卵巢小卵泡数目越多,血清中抗穆勒氏管荷尔蒙(AMH)浓度越高。下列情况有可能会减少AMH的浓度:年龄增加,体重上升,注射促性腺激素,接受化疗或放射线治疗以及切除卵巢。而下列情况会增加AMH的浓度:如多囊性卵巢。而怀孕或口服避孕药并不会影响AMH的浓度。

抗穆勒氏管荷尔蒙比起其他预测卵巢功能的方法有哪些其他优势呢?第一:随着年龄的增加,卵巢功能会逐渐衰退,抗穆勒氏管荷尔蒙值(AMH)也随之下降。在所有检测卵巢功能的方法中,AMH值能最早筛检出巢的衰竭;第二:它的浓度不受到月经周期的影响,因而任何时期抽血浓度都一样稳定;第三:年轻女性检查AMH值能筛检出卵巢功能提早衰退的女性,以便即时治疗生子,以免蹉跎岁月,等到计划生子时已经为时已晚。综合以上的研究显示,抗穆勒氏管荷尔蒙为预测卵巢功能的一项重要指标。

💖 我们的成果 (小于等于38岁女性) 💖

人工受孕(IUI)—怀孕率约 20%
.试管婴儿(IVF)—怀孕率约50%
.解冻胚胎植入(FET)—怀孕率约55%
.试管婴儿累积活产率—约57%

我们的团队


林明輝 醫師

现职
马偕纪念医院妇产部部主任
马偕纪念医院不孕症学科科主任
马偕纪念医院妇产部资深主治医师
台湾生殖医学会理事
马偕医学院临床副教授

专长
不孕症、人工生殖(试管婴儿)、
生殖内分泌、腹腔镜及子宫镜手术

学经历
高雄医学大学医学系毕业
马偕纪念医院妇产部住院医师
马偕纪念医院妇产部主治医师
美国东维吉尼亚医学院及琼斯生殖医学中心(Jones Institute)研究员
日本川崎医院研修

李國光 醫師

现职
马偕纪念医院不孕症科资深主治医师
台北医学大学医学系副教授
教育部定副教授

专长
不孕症、人工生殖(试管婴儿)、
生殖内分泌

学经历
高雄医学院毕业
美国加州大学欧文医学院长堤医学中心生殖医学研究员
台湾生殖医学会理事长、常务理事
马偕纪念医院不孕症学科主任
马偕纪念医院 妇产部主任

李日升 醫師

现职
马偕纪念医院不孕症科主治医师
人工生殖试管婴儿施术医师
台湾妇产科医学会专科医师

专长
不孕症、人工生殖(试管婴儿)、
冷冻卵子、一般妇产科

学经历
台北医学大学医学系毕
马偕医院妇产科住院医师
马偕医院妇产科总医师训练
马偕医院不孕症科研究医师训练

洪子渝 醫師

现职
马偕纪念医院不孕症科主治医师

专长
生殖内分泌、冷冻卵子、生育保存、不孕症、 试管婴儿、子宫腔镜、腹腔镜、一般妇产科

学经历
阳明大学医学系毕业
马偕纪念医院妇产科住院医师及总医师
马偕纪念医院不孕症科研究医师

邱上琪 醫師

现职
淡水馬偕紀念醫院不孕症科主治醫師

专长
生殖内分泌、冷冻卵子、生育保存、不孕症、 试管婴儿、子宫腔镜、一般妇产科

学经历
加拿大多伦多大学荣誉理学士
欧盟波兰波兹南医学大学医学士
马偕医院妇产科住院医师
马偕医院妇产科总医师训练
马偕医院不孕症科研究医师训练